Neuronal calcium sensor-1 potentiates glucose-dependent exocytosis in pancreatic cells through activation of phosphatidylinositol 4-kinase
نویسندگان
چکیده
*Lilly Research Laboratories, Essener Bogen 7, D-22419 Hamburg, Germany; †Department of Pharmacology, University of Aarhus, DK-8000 Aarhus C, Denmark; ‡The Rolf Luft Center for Diabetes Research, Department of Molecular Medicine, Karolinska Institutet, SE-171 76 Stockholm, Sweden; §Department of Neuroscience, Karolinska Institutet, SE-171 77 Stockholm, Sweden; and ¶Center for Learning and Memory, University of Texas, Austin, TX 78712
منابع مشابه
Phosphatidylinositol 4-kinase serves as a metabolic sensor and regulates priming of secretory granules in pancreatic beta cells.
Insulin secretion is controlled by the beta cell's metabolic state, and the ability of the secretory granules to undergo exocytosis increases during glucose stimulation in a membrane potential-independent fashion. Here, we demonstrate that exocytosis of insulin-containing secretory granules depends on phosphatidylinositol 4-kinase (PI 4-kinase) activity and that inhibition of this enzyme suppre...
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